Growth
factors and cytokines in bone cell metabolism.
Canalis E, McCarthy
TL, Centrella M.
Research Laboratory,
Saint Francis Hospital and Medical Center, Hartford, Connecticut 06105.
Growth factors
regulate the growth and differentiated function of cells. Skeletal
cells synthesize fibroblast growth factor, platelet-derived growth
factor, insulin-like growth factor, transforming growth factor beta,
and additional cytokines. Some of the growth factors produced by bone
cells primarily stimulate bone cell replication, whereas others also
affect the differentiated function of the osteoblast. Skeletal growth
factors also may play a role in the pathogenesis and therapy of metabolic
bone disease.
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