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 Articles
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Rotaviral
antibodies in the treatment of acute rotaviral gastroenteritis.
Ylitalo S, Uhari
M, Rasi S, Pudas J, Leppaluoto J.
Department of Paediatrics, University of Oulu, Finland.
The efficacy of hyperimmune bovine colostrum received from cows immunized
with simian rotavirus SA11 in the treatment of rotavirus gastroenteritis
was compared in a randomized double-blind trial to colostrum and ordinary
milk preparations. One hundred and thirty-five children aged 6-30
months with rotaviral gastroenteritis received either hyperimmune
bovine colostrum (n=42), ordinary colostrum (n=42) or milk (n=41)
as a 100 ml solution four times/d for 4 d. Even though the differences
were in favour of hyperimmune bovine colostrum in all the variables
evaluated [greater weight gain (403 vs 343 g), shorter duration of
diarrhoea (3.1 vs 3.6 d), fewer stools during 6 d (11.5 vs 13.6) and
fewer stools during the first 3 d (9.3 vs 11.3)], all the differences
were statistically insignificant. Differences of this size are clinically
unimportant in well-nourished immunocompetent children, but we suggest
that the hyperimmune bovine colostrum tested in our trial had some
effects in the treatment of acute rotaviral gastroenteritis and should
be evaluated further.
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