Colostrum
and milk-derived peptide growth factors for the treatment of gastrointestinal
disorders
Playford RJ,
Macdonald CE, Johnson WS.
Department of Gastroenterology, Imperial College School of Medicine,
Hammersmith
Hospital, London, UK. r.playford@ic.ac.uk
Colostrum is the specific first diet of mammalian neonates and is
rich in immunoglobulins, antimicrobial peptides, and growth factors.
In this article we review some of these constituents of human and
bovine colostrum in comparison with those of mature milk. Recent studies
suggest that colostral fractions, or individual peptides present in
colostrum, might be useful for the treatment of a wide variety of
gastrointestinal conditions, including inflammatory bowel disease,
nonsteroidal antiinflammatory drug-induced gut injury, and chemotherapy-induced
mucositis. We therefore discuss the therapeutic possibilities of using
whole colostrum, or individual peptides present in colostrum, for
the treatment of various gastrointestinal diseases and the relative
merits of the 2 approaches.
Articles
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