Promoting
effect of colostrum on the phagocytic activity of bovine polymorphonuclear
leukocytes in vitro
Sugisawa H, Itou
T, Sakai T.
Department of Preventive Veterinary Medicine and Animal Health, Nihon
University
School of Veterinary Medicine, Kanagawa, Japan.
Bovine colostrum contains a variety of essential nutrients, antibodies,
cytokines, hormones, and growth factors that are important for nutrient
supply, host defense, growth and for general neonatal adaptation.
We have investigated the effect of bovine colostrum on the phagocytic
activity for latex particles by normal peripheral blood polymorphonuclear
leukocytes using flow cytometric analysis. The phagocytosis promoting
effect was observed in colostrum. The promoting activity showed dose-dependent
increase up to 25% at a concentration of colostrum. This activity
was maximum in the colostrum obtained at parturition and gradually
decreased with the time course of lactation as well as IgG level.
Colostrum possessed the higher promoting activity than milk and normal
serum. These results indicate that bovine colostrum strongly activates
polymorphonuclear leukocyte phagocytosis, suggesting the concernment
with development of nonspecific immune system in newborns.
Copyright 2001 S. Karger
AG, Basel
PMID: 11223656 [PubMed - indexed for MEDLINE]
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